Introduction Bipolar disorder in children and adolescents is distinguished by a variable and complex clinical expression.Mood is difficult to assess, mood symptoms are often masked and signs of disorganization may be in the limelight.This can be more difficult when adolescents have intellectual disability (ID).Objectives This work aims to describe
We explored the collateral harm in Dutch children and adolescents during the COVID-19 pandemic from experience of paediatricians via an open question distributed via the website of the Dutch Paediatric Society.From the end of March till the first week of July, we received 51 reports of collateral harm involving mostly very young children with mainl
Abstract Background Xenograft samples used to test anti-cancer drug efficacies and toxicities in vivo contain an unknown mix of mouse and human cells.Evaluation of drug activity can be confounded by samples containing large amounts of contaminating mouse tissue.We have developed a real-time quantitative polymerase chain reaction (qPCR) Sweater assa
Histone modifications control the lytic gene expression of herpes simplex virus 1 (HSV-1).The heterochromatin mark, trimethylation of histone H3 on lysine (K) 9 (H3K9me3), is detected on HSV-1 genomes at early phases of infection to repress viral gene transcription.However, the components and mechanisms involved in the process are mostly unknown.In